InnateDB Protein
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IDBP-213297.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ace
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Protein Name
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angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
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Synonyms
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AW208573; CD143;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000001964
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InnateDB Gene
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IDBG-213293 (Ace)
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Protein Structure
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Function |
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm. {ECO:0000269PubMed:15665832, ECO:0000269PubMed:7753170, ECO:0000269PubMed:8642790}.
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Subcellular Localization |
Angiotensin-converting enzyme, soluble form: Secreted {ECO:0000250}.Cell membrane {ECO:0000269PubMed:23535237}; Single-pass type I membrane protein {ECO:0000269PubMed:23535237}. Cytoplasm {ECO:0000269PubMed:23535237}. Note=Detected in both cell membrane and cytoplasm in neurons.
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Disease Associations |
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Tissue Specificity |
Testis-specific isoform is expressed in spermatocytes, adult testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:87874
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InterPro |
IPR001548
Peptidase M2, peptidyl-dipeptidase A
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PFAM |
PF01401
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PRINTS |
PR00791
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P09470
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PhosphoSite |
PhosphoSite-P09470
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11421
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UniGene |
Mm.754
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RefSeq |
NP_033728
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MGI ID |
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MGI Symbol |
Ace
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OMIM |
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CCDS |
CCDS25544
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HPRD |
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IMGT |
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EMBL |
BC040404
J03940
J04946
J04947
M55333
M61094
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GenPept |
AAA37146
AAA37147
AAA37148
AAA37149
AAA37150
AAH40404
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