InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gh

Summary

InnateDB Protein

IDBP-213452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

growth hormone

Synonyms

Gh1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099360

InnateDB Gene

IDBG-213450 (Gh)

Protein Structure

UniProt Annotation

Function

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005131	growth hormone receptor binding
GO:0005179	hormone activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007405	neuroblast proliferation
GO:0007565	female pregnancy
GO:0009416	response to light stimulus
GO:0032094	response to food
GO:0032869	cellular response to insulin stimulus
GO:0034097	response to cytokine
GO:0040018	positive regulation of multicellular organism growth
GO:0043434	response to peptide hormone
GO:0045927	positive regulation of growth
GO:0048286	lung alveolus development
GO:0050769	positive regulation of neurogenesis
GO:0090031	positive regulation of steroid hormone biosynthetic process
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030141	secretory granule