InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gh

Summary

InnateDB Gene

IDBG-213450.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

growth hormone

Synonyms

Gh1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020713

Encoded Proteins

IDBP-213452

growth hormone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000259384:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106300271-106301865

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103071

ENSMUSP00000099360

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005131	growth hormone receptor binding
GO:0005179	hormone activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007405	neuroblast proliferation
GO:0007565	female pregnancy
GO:0009416	response to light stimulus
GO:0032094	response to food
GO:0032869	cellular response to insulin stimulus
GO:0034097	response to cytokine
GO:0040018	positive regulation of multicellular organism growth
GO:0043434	response to peptide hormone
GO:0045927	positive regulation of growth
GO:0048286	lung alveolus development
GO:0050769	positive regulation of neurogenesis
GO:0090031	positive regulation of steroid hormone biosynthetic process
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030141	secretory granule