Version 5.4
Mus musculus Protein: Ctsz
Summary
InnateDB Protein IDBP-213481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctsz
Protein Name cathepsin Z
Synonyms AI787083; AU019819; CTSX; D2Wsu143e;
Species Mus musculus
Ensembl Protein ENSMUSP00000016400
InnateDB Gene IDBG-213479 (Ctsz)
Protein Structure
UniProt Annotation
Function Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. {ECO:0000250}.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0060441 epithelial tube branching involved in lung morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1891190
InterPro IPR000668 Peptidase C1A, papain C-terminal
PFAM PF00112
PRINTS PR00705
PIRSF
SMART SM00645
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUU7
PhosphoSite PhosphoSite-
TrEMBL Q545I6
UniProt Splice Variant
Entrez Gene 64138
UniGene
RefSeq NP_071720
MGI ID
MGI Symbol Ctsz
OMIM
CCDS CCDS17152
HPRD
IMGT
EMBL AF136277 AF136278 AJ242663 AK002710 AK008370 AK010912 AK150329 AK150894 AK150947 AK151440 AK151585 AK151994 AK153147 AK159118 AK159618 AK160001 AK160028 AK166047 AK170963 BC008619 CH466551
GenPept AAF13143 AAF13144 AAH08619 BAB22302 BAB25633 BAB27263 BAE29471 BAE29940 BAE29981 BAE30402 BAE30525 BAE30858 BAE31757 BAE34834 BAE35234 BAE35549 BAE35571 BAE38541 BAE42144 CAB44494 EDL06678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca