Version 5.4
Mus musculus Gene: Ctsz
Summary
InnateDB Gene IDBG-213479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctsz
Gene Name cathepsin Z
Synonyms AI787083; AU019819; CTSX; D2Wsu143e
Species Mus musculus
Ensembl Gene ENSMUSG00000016256
Encoded Proteins
IDBP-213481
cathepsin Z
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101160:
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:174427493-174439039
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000016400 ENSMUSP00000016400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0060441 epithelial tube branching involved in lung morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101160
View Gene Order
ENSBTAG00000018784
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_196539
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9WUU7
TrEMBL Q545I6
UniProt Splice Variant
Entrez Gene 64138
UniGene
RefSeq NM_022325
OMIM
CCDS CCDS17152
HPRD
IMGT
MGI ID MGI:1891190
MGI Symbol Ctsz
EMBL AF136277 AF136278 AJ242663 AK002710 AK008370 AK010912 AK150329 AK150894 AK150947 AK151440 AK151585 AK151994 AK153147 AK159118 AK159618 AK160001 AK160028 AK166047 AK170963 BC008619 CH466551
GenPept AAF13143 AAF13144 AAH08619 BAB22302 BAB25633 BAB27263 BAE29471 BAE29940 BAE29981 BAE30402 BAE30525 BAE30858 BAE31757 BAE34834 BAE35234 BAE35549 BAE35571 BAE38541 BAE42144 CAB44494 EDL06678
RNA Seq Atlas 64138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca