InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Edn3

Summary

InnateDB Protein

IDBP-213501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edn3

Protein Name

endothelin 3

Synonyms

114CH19; ET-3; ls; PPET3; tmgc48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029030

InnateDB Gene

IDBG-213499 (Edn3)

Protein Structure

UniProt Annotation

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001755	neural crest cell migration
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0007166	cell surface receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010460	positive regulation of heart rate
GO:0014826	vein smooth muscle contraction
GO:0019229	regulation of vasoconstriction
GO:0030072	peptide hormone secretion
GO:0030182	neuron differentiation
GO:0030318	melanocyte differentiation
GO:0030334	regulation of cell migration
GO:0030593	neutrophil chemotaxis
GO:0042310	vasoconstriction
GO:0043406	positive regulation of MAP kinase activity
GO:0045840	positive regulation of mitosis
GO:0046887	positive regulation of hormone secretion
GO:0048016	inositol phosphate-mediated signaling
GO:0048070	regulation of developmental pigmentation