InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Edn3

Summary

InnateDB Gene

IDBG-213499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edn3

Gene Name

endothelin 3

Synonyms

114CH19; ET-3; ls; PPET3; tmgc48

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027524

Encoded Proteins

IDBP-213501

endothelin 3

IDBP-536542

endothelin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the endothelin family whose members encode proteins that act on G protein-coupled receptors. Endothelins are produced as large prepropolypeptide precursors that undergo a first cleavage by a subtilisin serine protease to form an inactive intermediate, which in turn is cleaved again by endothelin-converting enzyme 1 (ECE-1) to yield the active 21 amino acid peptide. This gene encodes a protein which is expressed in neural crest cells (NCC), binds to endothelin receptor b (Ednrb) and plays an essential role in the development of NCC-derived cell lineages including melanocytes and enteric neurons. Mutations in this gene are associated with terminal aganglionosis and white spotted coat in mice and Hirschsprung\'s disease and Waardenburg syndrome in humans. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:174760619-174784042

Strand

Forward strand

Band

Transcripts

ENSMUST00000029030	ENSMUSP00000029030
ENSMUST00000140908	ENSMUSP00000125602
ENSMUST00000137369
ENSMUST00000162473

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0001755	neural crest cell migration
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0007166	cell surface receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010460	positive regulation of heart rate
GO:0014826	vein smooth muscle contraction
GO:0019229	regulation of vasoconstriction
GO:0030072	peptide hormone secretion
GO:0030182	neuron differentiation
GO:0030318	melanocyte differentiation
GO:0030334	regulation of cell migration
GO:0030593	neutrophil chemotaxis
GO:0042310	vasoconstriction
GO:0043406	positive regulation of MAP kinase activity
GO:0045840	positive regulation of mitosis
GO:0046887	positive regulation of hormone secretion
GO:0048016	inositol phosphate-mediated signaling
GO:0048070	regulation of developmental pigmentation