InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx5

Summary

InnateDB Protein

IDBP-213552.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx5

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

Synonyms

2600009A06Rik; G17P1; Hlr1; HUMP68; p68;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021062

InnateDB Gene

IDBG-213550 (Ddx5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 147 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	147 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0003724	RNA helicase activity
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0001701	in utero embryonic development
GO:0006200	ATP catabolic process
GO:0007623	circadian rhythm
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045069	regulation of viral genome replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060765	regulation of androgen receptor signaling pathway
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:105037

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR012587 P68HR
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF08061

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite