Version 5.4
Mus musculus Protein: Cdh4
Summary
InnateDB Protein IDBP-213703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdh4
Protein Name cadherin 4
Synonyms AW120700; R-Cadh; R-cadherin; Rcad;
Species Mus musculus
Ensembl Protein ENSMUSP00000000314
InnateDB Gene IDBG-213701 (Cdh4)
Protein Structure
UniProt Annotation
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Distributed widely in mouse tissues with high levels present in brain, skeletal muscle and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007411 axon guidance
GO:0045773 positive regulation of axon extension
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:99218
InterPro IPR000233 Cadherin, cytoplasmic domain
IPR002126 Cadherin
IPR009124 Cadherin/Desmocollin
IPR014868 Cadherin prodomain
IPR015919 Cadherin-like
PFAM PF01049
PF00028
PF08758
PRINTS PR00205
PR01820
PIRSF
SMART SM00112
SM01055
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P39038
PhosphoSite PhosphoSite-P39038
TrEMBL
UniProt Splice Variant
Entrez Gene 12561
UniGene Mm.475793
RefSeq NP_033997
MGI ID
MGI Symbol Cdh4
OMIM
CCDS CCDS17164
HPRD
IMGT
EMBL D14888 X69966
GenPept BAA03605 CAA49589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca