InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdh4

Summary

InnateDB Gene

IDBG-213701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh4

Gene Name

cadherin 4

Synonyms

AW120700; R-Cadh; R-cadherin; Rcad

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000305

Encoded Proteins

IDBP-213703

cadherin 4

IDBP-263545

cadherin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179242:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:179442431-179899373

Strand

Forward strand

Band

Transcripts

ENSMUST00000000314	ENSMUSP00000000314
ENSMUST00000108911	ENSMUSP00000104539
ENSMUST00000124708
ENSMUST00000136411
ENSMUST00000129659

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005509	calcium ion binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007411	axon guidance
GO:0008150	biological_process
GO:0045773	positive regulation of axon extension