Version 5.4
Mus musculus Protein: Helz
Summary
InnateDB Protein IDBP-213708.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Helz
Protein Name helicase with zinc finger domain
Synonyms 3110078M01Rik; 9430093I07Rik; 9630002H22Rik; AI851979; DRHC;
Species Mus musculus
Ensembl Protein ENSMUSP00000074533
InnateDB Gene IDBG-213704 (Helz)
Protein Structure
UniProt Annotation
Function May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1925705
InterPro IPR000571 Zinc finger, CCCH-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00642
PRINTS
PIRSF
SMART SM00356
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DFV5
PhosphoSite PhosphoSite-Q6DFV5
TrEMBL Q6PAR9
UniProt Splice Variant
Entrez Gene 78455
UniGene Mm.490425
RefSeq NP_938040
MGI ID
MGI Symbol Helz
OMIM
CCDS CCDS25569
HPRD
IMGT
EMBL AB093209 AK033094 AL645947 BC021818 BC060114 BC076626 BC130582
GenPept AAH21818 AAH60114 AAH76626 AAI30583 BAC28150 BAC41393 CAM21447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca