InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Axin2

Summary

InnateDB Protein

IDBP-213784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Axin2

Protein Name

axin2

Synonyms

Axi1; Axil; Conductin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051331

InnateDB Gene

IDBG-213782 (Axin2)

Protein Structure

UniProt Annotation

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0070016	armadillo repeat domain binding
GO:0070411	I-SMAD binding

Biological Process

GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001957	intramembranous ossification
GO:0003139	secondary heart field specification
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009950	dorsal/ventral axis specification
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010942	positive regulation of cell death
GO:0030111	regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0032423	regulation of mismatch repair
GO:0034613	cellular protein localization
GO:0035412	regulation of catenin import into nucleus
GO:0035414	negative regulation of catenin import into nucleus
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042476	odontogenesis
GO:0043547	positive regulation of GTPase activity
GO:0043570	maintenance of DNA repeat elements
GO:0045668	negative regulation of osteoblast differentiation
GO:0048255	mRNA stabilization
GO:0061181	regulation of chondrocyte development
GO:0070602	regulation of centromeric sister chromatid cohesion
GO:0071407	cellular response to organic cyclic compound
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030877	beta-catenin destruction complex

Protein Structure and Domains

PDB ID

MGI:1270862

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001158 DIX domain
IPR014936 Axin beta-catenin binding
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00778
PF08833

PRINTS

PR01301

PIRSF

SMART

SM00021
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt