Version 5.4
| Mus musculus Protein: Ntsr1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-213843.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Ntsr1 | ||||||||||
| Protein Name | neurotensin receptor 1 | ||||||||||
| Synonyms | NT-1R; NTR-1; NTR1; | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000029084 | ||||||||||
| InnateDB Gene | IDBG-213841 (Ntsr1) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:97386 | ||||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR003984 Neurotensin receptor IPR003985 Neurotensin type 1 receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019426 7TM GPCR, serpentine receptor class v (Srv) |
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| PFAM |
PF00001
PF10323 |
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| PRINTS |
PR00237
PR01479 PR01480 |
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| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | O88319 | ||||||||||
| PhosphoSite | PhosphoSite-O88319 | ||||||||||
| TrEMBL | Q9QZQ2 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 18216 | ||||||||||
| UniGene | Mm.301712 | ||||||||||
| RefSeq | NP_061236 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Ntsr1 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS17177 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AB017027 AF172326 BC138630 BC138633 CH466626 | ||||||||||
| GenPept | AAD51806 AAI38631 AAI38634 BAA33013 EDL07336 | ||||||||||