InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dido1

Summary

InnateDB Protein

IDBP-213882.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dido1

Protein Name

death inducer-obliterator 1

Synonyms

6720461J16Rik; D130048F08Rik; DATF-1; Datf1; DIO-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048315

InnateDB Gene

IDBG-213878 (Dido1)

Protein Structure

UniProt Annotation

Function

Required for early embryonic stem cell development (By similarity). Putative transcription factor, weakly pro-apoptotic when overexpressed. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis (By similarity). Translocates to the nucleus after pro-apoptotic stimuli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at intermediate levels.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle

Protein Structure and Domains

PDB ID

MGI:1344352

InterPro

IPR003618 Transcription elongation factor S-II, central domain
IPR012921 Spen paralogue and orthologue SPOC, C-terminal
IPR017890 Transcription elongation factor S-IIM

PFAM

PF07500
PF07744

PRINTS

PIRSF

SMART

SM00510

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C9B9