Version 5.4
Mus musculus Protein: Arfgap1
Summary
InnateDB Protein IDBP-213933.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arfgap1
Protein Name ADP-ribosylation factor GTPase activating protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000029092
InnateDB Gene IDBG-213931 (Arfgap1)
Protein Structure
UniProt Annotation
Function GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with the Golgi complex. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0031965 nuclear membrane
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:2183559
InterPro IPR001164 Arf GTPase activating protein
PFAM PF01412
PRINTS PR00405
PIRSF
SMART SM00105
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPJ9
PhosphoSite PhosphoSite-Q9EPJ9
TrEMBL
UniProt Splice Variant
Entrez Gene 228998
UniGene Mm.33765
RefSeq NP_665703
MGI ID
MGI Symbol Arfgap1
OMIM
CCDS CCDS17190
HPRD
IMGT
EMBL AJ401461 AK030295 AK030520 AK145879 AK168007 BX649560
GenPept BAC26883 BAC27002 BAE26720 BAE39994 CAC18721 CAM23227 CAM23229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca