Version 5.4
Mus musculus Gene: Arfgap1
Summary
InnateDB Gene IDBG-213931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arfgap1
Gene Name ADP-ribosylation factor GTPase activating protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027575
Encoded Proteins
IDBP-213933
ADP-ribosylation factor GTPase activating protein 1
IDBP-263634
ADP-ribosylation factor GTPase activating protein 1
IDBP-263636
ADP-ribosylation factor GTPase activating protein 1
IDBP-263638
ADP-ribosylation factor GTPase activating protein 1
IDBP-263640
ADP-ribosylation factor GTPase activating protein 1
IDBP-788655
ADP-ribosylation factor GTPase activating protein 1
IDBP-788656
ADP-ribosylation factor GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101199:
The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:180967225-180982526
Strand Forward strand
Band H4
Transcripts
ENSMUST00000029092 ENSMUSP00000029092
ENSMUST00000108862 ENSMUSP00000104490
ENSMUST00000108861 ENSMUSP00000104489
ENSMUST00000108860 ENSMUSP00000104488
ENSMUST00000108859 ENSMUSP00000104487
ENSMUST00000145629
ENSMUST00000136590
ENSMUST00000132627
ENSMUST00000138706
ENSMUST00000150507
ENSMUST00000134519
ENSMUST00000148908
ENSMUST00000185115 ENSMUSP00000139222
ENSMUST00000184394 ENSMUSP00000138843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0031965 nuclear membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101199
View Gene Order
ENSBTAG00000004916
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
REACT_207127
Golgi to ER Retrograde Transport pathway
REACT_227904
COPI Mediated Transport pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_11096
COPI Mediated Transport pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
REACT_11208
Golgi to ER Retrograde Transport pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.33765
RefSeq NM_001177706 NM_001177707 NM_001177708 NM_001177709 NM_001177710 NM_145760 XM_006500595 XM_006500598
OMIM
CCDS CCDS17190 CCDS50842 CCDS50843
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca