InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrna4

Summary

InnateDB Protein

IDBP-213953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna4

Protein Name

cholinergic receptor, nicotinic, alpha polypeptide 4

Synonyms

Acra-4; Acra4; EBN1; ENFL1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066338

InnateDB Gene

IDBG-213951 (Chrna4)

Protein Structure

UniProt Annotation

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015464	acetylcholine receptor activity

Biological Process

GO:0001508	action potential
GO:0001666	response to hypoxia
GO:0006281	DNA repair
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007271	synaptic transmission, cholinergic
GO:0007585	respiratory gaseous exchange
GO:0007626	locomotory behavior
GO:0014059	regulation of dopamine secretion
GO:0019233	sensory perception of pain
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0035640	exploration behavior
GO:0042113	B cell activation
GO:0042391	regulation of membrane potential
GO:0050877	neurological system process
GO:0050890	cognition
GO:0051899	membrane depolarization
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:87888

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O70174