InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrna4

Summary

InnateDB Gene

IDBG-213951.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna4

Gene Name

cholinergic receptor, nicotinic, alpha polypeptide 4

Synonyms

Acra-4; Acra4; EBN1; ENFL1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027577

Encoded Proteins

IDBP-213953

cholinergic receptor, nicotinic, alpha polypeptide 4

IDBP-263656

cholinergic receptor, nicotinic, alpha polypeptide 4

IDBP-538038

cholinergic receptor, nicotinic, alpha polypeptide 4

IDBP-535094

cholinergic receptor, nicotinic, alpha polypeptide 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101204:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:181018380-181043546

Strand

Reverse strand

Band

Transcripts

ENSMUST00000067120	ENSMUSP00000066338
ENSMUST00000108851	ENSMUSP00000104479
ENSMUST00000135766	ENSMUSP00000125724
ENSMUST00000124400	ENSMUSP00000123043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015464	acetylcholine receptor activity

Biological Process

GO:0001508	action potential
GO:0001666	response to hypoxia
GO:0006281	DNA repair
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007271	synaptic transmission, cholinergic
GO:0007585	respiratory gaseous exchange
GO:0007626	locomotory behavior
GO:0014059	regulation of dopamine secretion
GO:0019233	sensory perception of pain
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0035640	exploration behavior
GO:0042113	B cell activation
GO:0042391	regulation of membrane potential
GO:0050877	neurological system process
GO:0050890	cognition
GO:0051899	membrane depolarization
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane