InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map2k6

Summary

InnateDB Protein

IDBP-213979.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Map2k6

Protein Name

mitogen-activated protein kinase kinase 6

Synonyms

MEK6; MKK6; Prkmk6; SAPKK3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097831

InnateDB Gene

IDBG-213977 (Map2k6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0002931	response to ischemia
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0060048	cardiac muscle contraction
GO:0072709	cellular response to sorbitol

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1346870

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A2AGS2

UniProt Splice Variant

Entrez Gene

26399

UniGene

Mm.474817

RefSeq

MGI ID

MGI Symbol

Map2k6

OMIM

CCDS

HPRD

IMGT

EMBL

AL603826 AL691461

GenPept