InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnj2

Summary

InnateDB Protein

IDBP-213990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnj2

Protein Name

potassium inwardly-rectifying channel, subfamily J, member 2

Synonyms

IRK1; Kcnf1; Kir2.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037192

InnateDB Gene

IDBG-213988 (Kcnj2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0042802	identical protein binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Biological Process

GO:0006813	potassium ion transport
GO:0010107	potassium ion import
GO:0014861	regulation of skeletal muscle contraction via regulation of action potential
GO:0015693	magnesium ion transport
GO:0051289	protein homotetramerization
GO:0055119	relaxation of cardiac muscle
GO:0060306	regulation of membrane repolarization
GO:0071260	cellular response to mechanical stimulus
GO:0071805	potassium ion transmembrane transport
GO:0086001	cardiac muscle cell action potential
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086011	membrane repolarization during action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090076	relaxation of skeletal muscle
GO:1901381	positive regulation of potassium ion transmembrane transport

Cellular Component

GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0014704	intercalated disc
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0030425	dendrite
GO:0031224	intrinsic component of membrane
GO:0043025	neuronal cell body
GO:0043197	dendritic spine

Protein Structure and Domains

PDB ID

MGI:104744

InterPro

IPR003271 Potassium channel, inwardly rectifying, Kir2.1
IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
IPR014756 Immunoglobulin E-set
IPR016449 Potassium channel, inwardly rectifying, Kir

PFAM

PF08466
PF01007

PRINTS

PR01324
PR01320

PIRSF

PIRSF005465

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt