InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnj2

Summary

InnateDB Gene

IDBG-213988.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnj2

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 2

Synonyms

IRK1; Kcnf1; Kir2.1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041695

Encoded Proteins

IDBP-213990

potassium inwardly-rectifying channel, subfamily J, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123700:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:111066164-111076821

Strand

Forward strand

Band

Transcripts

ENSMUST00000042970

ENSMUSP00000037192

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0042802	identical protein binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

Biological Process

GO:0006813	potassium ion transport
GO:0010107	potassium ion import
GO:0014861	regulation of skeletal muscle contraction via regulation of action potential
GO:0015693	magnesium ion transport
GO:0051289	protein homotetramerization
GO:0055119	relaxation of cardiac muscle
GO:0060306	regulation of membrane repolarization
GO:0071260	cellular response to mechanical stimulus
GO:0071805	potassium ion transmembrane transport
GO:0086001	cardiac muscle cell action potential
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086011	membrane repolarization during action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090076	relaxation of skeletal muscle
GO:1901381	positive regulation of potassium ion transmembrane transport

Cellular Component

GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0014704	intercalated disc
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0030425	dendrite
GO:0031224	intrinsic component of membrane
GO:0043025	neuronal cell body
GO:0043197	dendritic spine