InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL31RA

Summary

InnateDB Protein

IDBP-21406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL31RA

Protein Name

interleukin 31 receptor A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351935

InnateDB Gene

IDBG-21402 (IL31RA)

Protein Structure

UniProt Annotation

Function

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. {ECO:0000269PubMed:11877449, ECO:0000269PubMed:14504285, ECO:0000269PubMed:15184896, ECO:0000269PubMed:15194700, ECO:0000269PubMed:15627637}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. {ECO:0000269PubMed:19690585}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells and by macrophages (at protein level). {ECO:0000269PubMed:11877449, ECO:0000269PubMed:14504285, ECO:0000269PubMed:15184896, ECO:0000269PubMed:16461143}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019955	cytokine binding

Biological Process

GO:0000165	MAPK cascade
GO:0006952	defense response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007259	JAK-STAT cascade
GO:0008284	positive regulation of cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0030224	monocyte differentiation
GO:0030225	macrophage differentiation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042592	homeostatic process
GO:0043031	negative regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated