Version 5.4
Homo sapiens Gene: IL31RA
Summary
InnateDB Gene IDBG-21402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL31RA
Gene Name interleukin 31 receptor A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164509
Encoded Proteins
IDBP-21404
interleukin 31 receptor A
IDBP-21406
interleukin 31 receptor A
IDBP-21408
interleukin 31 receptor A
IDBP-236652
interleukin 31 receptor A
IDBP-236654
interleukin 31 receptor A
IDBP-367598
interleukin 31 receptor A
IDBP-482338
interleukin 31 receptor A
IDBP-809261
interleukin 31 receptor A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:55851379-55922853
Strand Forward strand
Band q11.2
Transcripts
ENST00000354961 ENSP00000347047
ENST00000359040 ENSP00000351935
ENST00000297015 ENSP00000297015
ENST00000396836 ENSP00000380048
ENST00000396834 ENSP00000380046
ENST00000447346 ENSP00000415900
ENST00000490985 ENSP00000427533
ENST00000611895 ENSP00000479432
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019955 cytokine binding
Biological Process
GO:0000165 MAPK cascade
GO:0006952 defense response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007259 JAK-STAT cascade
GO:0008284 positive regulation of cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042592 homeostatic process
GO:0043031 negative regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050377
View Gene Order
ENSBTAG00000004351
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.55378
RefSeq NM_001242636 NM_001242637 NM_001242638 NM_001242639 NM_001297570 NM_139017 XM_005248428 XM_006714528
HUGO
OMIM
CCDS CCDS3970 CCDS56365 CCDS56366 CCDS56367 CCDS75244 CCDS75245
HPRD 17145
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca