Version 5.4
Mus musculus Protein: Cd300a
Summary
InnateDB Protein IDBP-214152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd300a
Protein Name CD300A antigen
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036773
InnateDB Gene IDBG-214150 (Cd300a)
Protein Structure
UniProt Annotation
Function Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. {ECO:0000269PubMed:12874256, ECO:0000269PubMed:12893283, ECO:0000269PubMed:16339535}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12874256, ECO:0000269PubMed:12893283}; Single-pass type I membrane protein {ECO:0000269PubMed:12874256, ECO:0000269PubMed:12893283}.
Disease Associations
Tissue Specificity Present on the surface of the majority of myeloid cells and a subset of B-cells. Present on the surface of NK cells after IL-12 stimulation. {ECO:0000269PubMed:12874256, ECO:0000269PubMed:12893283, ECO:0000269PubMed:16339535}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
Biological Process
GO:0002552 serotonin secretion by mast cell
GO:0006898 receptor-mediated endocytosis
GO:0014063 negative regulation of serotonin secretion
GO:0043305 negative regulation of mast cell degranulation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
Protein Structure and Domains
PDB ID MGI:2443411
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6SJQ0
PhosphoSite PhosphoSite-Q6SJQ0
TrEMBL
UniProt Splice Variant
Entrez Gene 217303
UniGene Mm.448323
RefSeq XP_006533132
MGI ID
MGI Symbol Cd300a
OMIM
CCDS
HPRD
IMGT
EMBL AB065156 AB091765 AB091766 AB095675 AK045869 AL669969 AY457054 BC139296 BC139297
GenPept AAI39297 AAI39298 AAR27945 BAC22595 BAC32515 BAC77074 BAC77075 BAC80268 CAM18755 CAM18756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca