InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tcea2

Summary

InnateDB Protein

IDBP-214198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcea2

Protein Name

transcription elongation factor A (SII), 2

Synonyms

AI326274; S-II-T1; SII-T1; Tceat;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099331

InnateDB Gene

IDBG-214196 (Tcea2)

Protein Structure

UniProt Annotation

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Testis and ovary specific. Specific to testicular germ cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

MGI:107368

InterPro

IPR001222 Zinc finger, TFIIS-type
IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR003618 Transcription elongation factor S-II, central domain
IPR006289 Transcription elongation factor, TFIIS
IPR016492 Transcription elongation factor, TFIIS-related
IPR017890 Transcription elongation factor S-IIM
IPR017923 Transcription factor IIS, N-terminal

PFAM

PF01096
PF07500
PF08711

PRINTS

PIRSF

PIRSF006704

SMART

SM00440
SM00509
SM00510

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt