InnateDB Protein
|
IDBP-214297.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Ict1
|
Protein Name
|
immature colon carcinoma transcript 1
|
Synonyms
|
1110001A02Rik; 1110002E03Rik; MRP-L58;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000099325
|
InnateDB Gene
|
IDBG-214293 (Ict1)
|
Protein Structure
|
|
Function |
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Mitochondrion {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 234 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
234 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0003747
|
translation release factor activity
|
GO:0004045
|
aminoacyl-tRNA hydrolase activity
|
GO:0016150
|
translation release factor activity, codon nonspecific
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1915822
|
InterPro |
IPR000352
Peptide chain release factor class I/class II
|
PFAM |
PF00472
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8R035
|
PhosphoSite |
PhosphoSite-Q8R035
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
68572
|
UniGene |
Mm.271062
|
RefSeq |
NP_081005
|
MGI ID |
1J26
|
MGI Symbol |
Ict1
|
OMIM |
|
CCDS |
CCDS25632
|
HPRD |
|
IMGT |
|
EMBL |
AK003192
AK003286
AK160697
AL603828
AL627096
BC028523
CH466558
|
GenPept |
AAH28523
BAB22632
BAB22691
BAE35961
CAM13810
CAM13811
CAM22618
CAM22619
EDL34481
EDL34486
|
|
|