Version 5.4
Mus musculus Protein: Srp68
Summary
InnateDB Protein IDBP-214437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srp68
Protein Name signal recognition particle 68
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021133
InnateDB Gene IDBG-214435 (Srp68)
Protein Structure
UniProt Annotation
Function Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005047 signal recognition particle binding
GO:0008312 7S RNA binding
GO:0030942 endoplasmic reticulum signal peptide binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0042493 response to drug
Cellular Component
GO:0005730 nucleolus
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
Protein Structure and Domains
PDB ID MGI:1917447
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMA6
PhosphoSite PhosphoSite-Q8BMA6
TrEMBL Q8K258
UniProt Splice Variant
Entrez Gene 217337
UniGene Mm.29655
RefSeq NP_666144
MGI ID
MGI Symbol Srp68
OMIM
CCDS CCDS25662
HPRD
IMGT
EMBL AK033010 AL645861 AL669925 BC033573 BC070422 CH466558
GenPept AAH33573 AAH70422 BAC28124 CAM16383 CAM16795 EDL34568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca