Version 5.4
Mus musculus Protein: Rhbdf2
Summary
InnateDB Protein IDBP-214495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhbdf2
Protein Name rhomboid 5 homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099318
InnateDB Gene IDBG-214493 (Rhbdf2)
Protein Structure
UniProt Annotation
Function Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. {ECO:0000269PubMed:21439629}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:21439629}; Multi-pass membrane protein {ECO:0000269PubMed:21439629}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
GO:0050709 negative regulation of protein secretion
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2442473
InterPro IPR022241 Rhomboid serine protease
IPR022764 Peptidase S54, rhomboid domain
PFAM PF12595
PF01694
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80WQ6
PhosphoSite PhosphoSite-Q80WQ6
TrEMBL
UniProt Splice Variant
Entrez Gene 217344
UniGene Mm.89695
RefSeq NP_001161152
MGI ID
MGI Symbol Rhbdf2
OMIM
CCDS CCDS25672
HPRD
IMGT
EMBL AK028872 AK171085 AL607039 AY167043 BC031398 BC052182
GenPept AAH31398 AAH52182 AAO34122 BAC26163 BAE42238 CAM20511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca