Version 5.4
Mus musculus Gene: Rhbdf2
Summary
InnateDB Gene IDBG-214493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhbdf2
Gene Name rhomboid 5 homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020806
Encoded Proteins
IDBP-214495
rhomboid 5 homolog 2 (Drosophila)
IDBP-214499
rhomboid 5 homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22550345
Rhbdf2 is required for the secretion of Tnf in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 22550345
[Homo sapiens] RHBDF2 is required for the secretion of TNF in macrophages. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129667:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:116598165-116627019
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000103029 ENSMUSP00000099318
ENSMUST00000103028 ENSMUSP00000099317
ENSMUST00000138125
ENSMUST00000126819
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
GO:0050709 negative regulation of protein secretion
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129667
View Gene Order
ENSBTAG00000003436
Not yet available
Cross-References
SwissProt Q80WQ6
TrEMBL
UniProt Splice Variant
Entrez Gene 217344
UniGene Mm.89695
RefSeq NM_172572 NM_001167680
OMIM
CCDS CCDS25672
HPRD
IMGT
MGI ID MGI:2442473
MGI Symbol Rhbdf2
EMBL AK028872 AK171085 AL607039 AY167043 BC031398 BC052182
GenPept AAH31398 AAH52182 AAO34122 BAC26163 BAE42238 CAM20511
RNA Seq Atlas 217344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca