InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sept9

Summary

InnateDB Protein

IDBP-214560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sept9

Protein Name

septin 9

Synonyms

Msf; MSF1; PNUTL4; Sint1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097767

InnateDB Gene

IDBG-214554 (Sept9)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:17546647}. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes with actin stress fibers.

Disease Associations

Note=Putative proto-oncogene involved in T-cell lymphomagenesis. May play a role in leukemogenesis.

Tissue Specificity

Expressed in all tissues examined except muscle. Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain. {ECO:0000269PubMed:10666245, ECO:0000269PubMed:12039034}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0007049	cell cycle
GO:0051291	protein heterooligomerization
GO:0051301	cell division

Cellular Component

GO:0001725	stress fiber
GO:0005874	microtubule
GO:0031105	septin complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1858222

InterPro

IPR000038 Cell division protein GTP binding
IPR000795 Elongation factor, GTP-binding domain
IPR004881 Ribosome biogenesis GTPase RsgA, putative
IPR006073 GTP binding domain
IPR006703 AIG1
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00735
PF00009
PF03193
PF01926
PF04548

PRINTS

PR00315
PR00326

PIRSF

PIRSF006698

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt