InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Socs3

Summary

InnateDB Protein

IDBP-214606.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Socs3

Protein Name

suppressor of cytokine signaling 3

Synonyms

Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059129

InnateDB Gene

IDBG-214604 (Socs3)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to recognize IL6ST. {ECO:0000250, ECO:0000269PubMed:10490101, ECO:0000269PubMed:10821852, ECO:0000269PubMed:12754505, ECO:0000269PubMed:12847520, ECO:0000269PubMed:9889194}.

Subcellular Localization

Disease Associations

Tissue Specificity

Low expression in lung, spleen and thymus. Expressed in Th2 but not TH1 cells. {ECO:0000269PubMed:12242343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	40 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0007259	JAK-STAT cascade
GO:0009968	negative regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0043066	negative regulation of apoptotic process
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060674	placenta blood vessel development
GO:0060707	trophoblast giant cell differentiation
GO:0060708	spongiotrophoblast differentiation