InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hgs

Summary

InnateDB Protein

IDBP-214823.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hgs

Protein Name

HGF-regulated tyrosine kinase substrate

Synonyms

Hgr; Hrs; ZFYVE8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026900

InnateDB Gene

IDBG-214821 (Hgs)

Protein Structure

UniProt Annotation

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. {ECO:0000269PubMed:11094085}.

Subcellular Localization

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous expression in adult and fetal tissues with higher expression in testis. {ECO:0000269PubMed:7565774, ECO:0000269PubMed:9630564}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	138 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0008333	endosome to lysosome transport
GO:0046426	negative regulation of JAK-STAT cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030141	secretory granule
GO:0031901	early endosome membrane
GO:0032585	multivesicular body membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:104681

InterPro

IPR000306 FYVE zinc finger
IPR002014 VHS
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011011 Zinc finger, FYVE/PHD-type
IPR017073 Ubiquitin binding protein, Hrs/VPS27
IPR017455 Zinc finger, FYVE-related
IPR018205 VHS subgroup
IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain

PFAM

PF01363
PF00790
PF02809
PF12210

PRINTS

PIRSF

PIRSF036956

SMART

SM00064
SM00726
SM00288

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt