InnateDB Protein
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IDBP-214844.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Arhgdia
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Protein Name
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Rho GDP dissociation inhibitor (GDI) alpha
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000063714
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InnateDB Gene
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IDBG-214842 (Arhgdia)
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Protein Structure
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Function |
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269PubMed:19029984, ECO:0000269PubMed:22628549, ECO:0000269PubMed:23434736}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:23434736}.
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Disease Associations |
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Tissue Specificity |
In kidney glomerulus, expressed in podocytes and mesangial cells. {ECO:0000269PubMed:19029984, ECO:0000269PubMed:23434736}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2178103
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InterPro |
IPR000406
RHO protein GDP dissociation inhibitor
IPR014756
Immunoglobulin E-set
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PFAM |
PF02115
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PRINTS |
PR00492
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99PT1
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PhosphoSite |
PhosphoSite-Q99PT1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
192662
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UniGene |
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RefSeq |
XP_006532612
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MGI ID |
4F38
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MGI Symbol |
Arhgdia
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OMIM |
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CCDS |
CCDS25743
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HPRD |
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IMGT |
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EMBL |
AB055070
AK075656
AK077343
AK143516
AK156819
AK165241
AK170553
AK170718
AK172140
AL663030
BC004732
BC086755
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GenPept |
AAH04732
AAH86755
BAB21527
BAC35881
BAC36761
BAE25410
BAE33865
BAE38098
BAE41876
BAE41976
BAE42844
CAM27085
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