InnateDB Protein
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IDBP-214861.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sirt7
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Protein Name
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sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000079093
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InnateDB Gene
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IDBG-214859 (Sirt7)
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Protein Structure
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Function |
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions (By similarity). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. {ECO:0000250, ECO:0000269PubMed:16618798, ECO:0000269PubMed:18239138}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000269PubMed:16618798}. Note=Located close to the nuclear membrane when in the cytoplasm (By similarity). Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in liver, spleen and testis. Detected in embryos. {ECO:0000269PubMed:16618798}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 630 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
630 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0007072
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positive regulation of transcription on exit from mitosis
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GO:0009303
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rRNA transcription
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GO:0070932
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histone H3 deacetylation
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GO:0070933
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histone H4 deacetylation
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Cellular Component |
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PDB ID |
MGI:2385849
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InterPro |
IPR003000
Sirtuin family
IPR026590
Sirtuin family, catalytic core domain
IPR029035
DHS-like NAD/FAD-binding domain
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PFAM |
PF02146
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BKJ9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A3KMC9
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UniProt Splice Variant |
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Entrez Gene |
209011
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UniGene |
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RefSeq |
NP_694696
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MGI ID |
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MGI Symbol |
Sirt7
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OMIM |
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CCDS |
CCDS49006
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HPRD |
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IMGT |
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EMBL |
AL663030
AY251540
BC026403
BC026650
BC040759
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GenPept |
AAH26403
AAH26650
AAH40759
AAP83960
CAM27095
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