InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sirt7

Summary

InnateDB Gene

IDBG-214859.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt7

Gene Name

sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025138

Encoded Proteins

IDBP-214861

sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)

IDBP-269298

sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)

IDBP-534716

sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187531:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120618372-120625240

Strand

Reverse strand

Band

Transcripts

ENSMUST00000080202	ENSMUSP00000079093
ENSMUST00000106183	ENSMUSP00000101789
ENSMUST00000153532
ENSMUST00000127882
ENSMUST00000133625
ENSMUST00000134255
ENSMUST00000146809	ENSMUSP00000120405
ENSMUST00000154714
ENSMUST00000152331
ENSMUST00000130743
ENSMUST00000153018

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 630 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	630 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0070403	NAD+ binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007072	positive regulation of transcription on exit from mitosis
GO:0009303	rRNA transcription
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation

Cellular Component

GO:0005730	nucleolus
GO:0005731	nucleolus organizer region
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000187531

View Gene Order

ENSBTAG00000000039

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_153056 XM_006532734

OMIM

CCDS

CCDS49006

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas