InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbr2

Summary

InnateDB Protein

IDBP-214898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbr2

Protein Name

carbonyl reductase 2

Synonyms

MLCR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026148

InnateDB Gene

IDBG-214896 (Cbr2)

Protein Structure

UniProt Annotation

Function

May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism. {ECO:0000269PubMed:7705352}.

Subcellular Localization

Mitochondrion matrix {ECO:0000269PubMed:8040004}.

Disease Associations

Tissue Specificity

Lung (ciliated cells, non-ciliated bronchiolar cells and type-II alveolar pneumocytes). Low expression in adipose tissue > testis = heart > kidney = spleen > brain = liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004090	carbonyl reductase (NADPH) activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0043621	protein self-association
GO:0050662	coenzyme binding

Biological Process

GO:0006116	NADH oxidation
GO:0008152	metabolic process
GO:0044237	cellular metabolic process
GO:0051262	protein tetramerization

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:107200

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF01370
PF00106
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt