InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LCMT1

Summary

InnateDB Protein

IDBP-21505.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCMT1

Protein Name

leucine carboxyl methyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370353

InnateDB Gene

IDBG-21503 (LCMT1)

Protein Structure

UniProt Annotation

Function

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. {ECO:0000269PubMed:10600115}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006479	protein methylation
GO:0006481	C-terminal protein methylation
GO:0031333	negative regulation of protein complex assembly
GO:0032259	methylation
GO:0042981	regulation of apoptotic process
GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR007213 Leucine carboxyl methyltransferase
IPR016651 Leucine carboxyl methyltransferase 1, LCMT1
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF04072

PRINTS

PIRSF

PIRSF016305

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UIC8