Version 5.4
Homo sapiens Gene: LCMT1
Summary
InnateDB Gene IDBG-21503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LCMT1
Gene Name leucine carboxyl methyltransferase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205629
Encoded Proteins
IDBP-21505
leucine carboxyl methyltransferase 1
IDBP-21509
leucine carboxyl methyltransferase 1
IDBP-231530
leucine carboxyl methyltransferase 1
IDBP-751442
IDBP-745805
IDBP-753547
IDBP-750661
IDBP-745840
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:25111729-25178231
Strand Forward strand
Band p12.1
Transcripts
ENST00000380966 ENSP00000370353
ENST00000380962 ENSP00000370349
ENST00000399069 ENSP00000382021
ENST00000564011 ENSP00000457741
ENST00000576382
ENST00000574450
ENST00000572761 ENSP00000459604
ENST00000575396 ENSP00000461754
ENST00000576625 ENSP00000461100
ENST00000577157
ENST00000572869
ENST00000570981 ENSP00000459851
ENST00000573435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006479 protein methylation
GO:0006481 C-terminal protein methylation
GO:0010906 regulation of glucose metabolic process
GO:0031333 negative regulation of protein complex assembly
GO:0032259 methylation
GO:0042981 regulation of apoptotic process
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030763
View Gene Order
ENSBTAG00000013169
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.337730
RefSeq NM_001032391 NM_016309 XM_005255354 XM_006721050
HUGO
OMIM
CCDS CCDS45445 CCDS45446
HPRD 17266
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca