InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRB3

Summary

InnateDB Protein

IDBP-21537.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRB3

Protein Name

crumbs homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000349204

InnateDB Gene

IDBG-21533 (CRB3)

Protein Structure

UniProt Annotation

Function

Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. {ECO:0000269PubMed:12771187, ECO:0000269PubMed:14718572}.

Subcellular Localization

Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.

Disease Associations

Tissue Specificity

Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate. {ECO:0000269PubMed:12527193, ECO:0000269PubMed:14718572}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017124	SH3 domain binding
GO:0019904	protein domain specific binding

Biological Process

GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome