Version 5.4
Homo sapiens Gene: CRB3
Summary
InnateDB Gene IDBG-21533.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRB3
Gene Name crumbs homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130545
Encoded Proteins
IDBP-21535
crumbs homolog 3 (Drosophila)
IDBP-21537
crumbs homolog 3 (Drosophila)
IDBP-766276
IDBP-765637
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6463777-6467221
Strand Forward strand
Band p13.3
Transcripts
ENST00000308243 ENSP00000310123
ENST00000356762 ENSP00000349204
ENST00000600229 ENSP00000472010
ENST00000598494 ENSP00000469707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017124 SH3 domain binding
GO:0019904 protein domain specific binding
Biological Process
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0070830 tight junction assembly
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0043234 protein complex
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000044279
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.150319
RefSeq NM_139161 NM_174881 XM_005259680
HUGO
OMIM
CCDS CCDS12166 CCDS12167
HPRD 16749
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca