Version 5.4
Homo sapiens Protein: AQP8
Summary
InnateDB Protein IDBP-21580.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP8
Protein Name aquaporin 8
Synonyms AQP-8;
Species Homo sapiens
Ensembl Protein ENSP00000219660
InnateDB Gene IDBG-21578 (AQP8)
Protein Structure
UniProt Annotation
Function Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed only in pancreas and colon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015250 water channel activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0015722 canalicular bile acid transport
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045177 apical part of cell
GO:0046691 intracellular canaliculus
Protein Structure and Domains
PDB ID
InterPro IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like
IPR023277 Aquaporin 8
PFAM PF00230
PRINTS PR00783
PR02020
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O94778
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 343
UniGene
RefSeq NP_001160
HUGO HGNC:642
OMIM 603750
CCDS CCDS10626
HPRD 04778
IMGT
EMBL AB013456 AF067797 BC040630
GenPept AAF19050 AAH40630 BAA34223

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca