InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF125

Summary

InnateDB Protein

IDBP-2179.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF125

Protein Name

ring finger protein 125

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000217740

InnateDB Gene

IDBG-2177 (RNF125)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15843525}.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells. {ECO:0000269PubMed:12974981, ECO:0000269PubMed:15843525}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding