InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CAPZA3

Summary

InnateDB Protein

IDBP-22044.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAPZA3

Protein Name

capping protein (actin filament) muscle Z-line, alpha 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326238

InnateDB Gene

IDBG-22042 (CAPZA3)

Protein Structure

UniProt Annotation

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed exclusively in testis and sperm. Highest expression is found in the neck region of ejaculated sperm with lower levels found in the tail and postacrosome region. {ECO:0000269PubMed:12029070}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0007286	spermatid development
GO:0030036	actin cytoskeleton organization
GO:0051016	barbed-end actin filament capping
GO:0051693	actin filament capping

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0008290	F-actin capping protein complex
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0071203	WASH complex