Version 5.4
Homo sapiens Gene: CAPZA3
Summary
InnateDB Gene IDBG-22042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPZA3
Gene Name capping protein (actin filament) muscle Z-line, alpha 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177938
Encoded Proteins
IDBP-22044
capping protein (actin filament) muscle Z-line, alpha 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:18738101-18739187
Strand Forward strand
Band p12.3
Transcripts
ENST00000317658 ENSP00000326238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0007286 spermatid development
GO:0030036 actin cytoskeleton organization
GO:0051016 barbed-end actin filament capping
GO:0051693 actin filament capping
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0008290 F-actin capping protein complex
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0071203 WASH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041791
View Gene Order
ENSBTAG00000013207
Not yet available
Cross-References
SwissProt Q96KX2
TrEMBL
UniProt Splice Variant
Entrez Gene 93661
UniGene
RefSeq NM_033328
HUGO HGNC:24205
OMIM 608722
CCDS CCDS8681
HPRD
IMGT
EMBL AB053259 AK058174 BC016745
GenPept AAH16745 BAB61901 BAB71703
RNA Seq Atlas 93661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca