InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA7A

Summary

InnateDB Protein

IDBP-22072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA7A

Protein Name

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

Synonyms

CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL;

Species

Homo sapiens

Ensembl Protein

ENSP00000261918

InnateDB Gene

IDBG-22070 (SEMA7A)

Protein Structure

UniProt Annotation

Function

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269PubMed:12879062, ECO:0000269PubMed:17377534, ECO:0000269PubMed:17671519}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10201933, ECO:0000269PubMed:17671519, ECO:0000269PubMed:9712866}; Lipid- anchor, GPI-anchor {ECO:0000269PubMed:10201933, ECO:0000269PubMed:17671519, ECO:0000269PubMed:9712866}; Extracellular side {ECO:0000269PubMed:10201933, ECO:0000269PubMed:17671519, ECO:0000269PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.

Disease Associations

Tissue Specificity

Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. {ECO:0000269PubMed:10201933, ECO:0000269PubMed:17671519, ECO:0000269PubMed:9712866}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0021988	olfactory lobe development
GO:0031175	neuron projection development
GO:0045773	positive regulation of axon extension
GO:0048675	axon extension
GO:0050727	regulation of inflammatory response
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade