InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEMA7A

Summary

InnateDB Gene

IDBG-22070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA7A

Gene Name

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

Synonyms

CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL

Species

Homo sapiens

Ensembl Gene

ENSG00000138623

Encoded Proteins

IDBP-22072

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

IDBP-583754

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

IDBP-599896

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

IDBP-746789

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:74409289-74434467

Strand

Reverse strand

Band

q24.1

Transcripts

ENST00000261918	ENSP00000261918
ENST00000543145	ENSP00000438966
ENST00000542748	ENSP00000441493
ENST00000569617
ENST00000567345	ENSP00000454365

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0021988	olfactory lobe development
GO:0031175	neuron projection development
GO:0045773	positive regulation of axon extension
GO:0048675	axon extension
GO:0050727	regulation of inflammatory response
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038264

View Gene Order

ENSBTAG00000011446

Not yet available

Pathways

NETPATH

REACTOME

REACT_19200

Other semaphorin interactions pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B3KMH6 F5GYX3 H3BMF9

UniProt Splice Variant

Entrez Gene

8482

UniGene

Hs.24640 Hs.735823

RefSeq

NM_001146030 NM_001146029 NM_003612 XM_005254721

HUGO

HGNC:10741

OMIM

607961

CCDS

CCDS53958 CCDS10262 CCDS53959

HPRD

07081

IMGT

EMBL

AC012435 AC090826 AK001895

GenPept

BAG50988

RNA Seq Atlas

8482