InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARID3B

Summary

InnateDB Protein

IDBP-22223.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID3B

Protein Name

AT rich interactive domain 3B (BRIGHT-like)

Synonyms

BDP; DRIL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000343126

InnateDB Gene

IDBG-22221 (ARID3B)

Protein Structure

UniProt Annotation

Function

Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. {ECO:0000269PubMed:16951138, ECO:0000269PubMed:17400556}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000269PubMed:10446990, ECO:0000269PubMed:17400556}.

Disease Associations

Tissue Specificity

Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level). {ECO:0000269PubMed:10446990, ECO:0000269PubMed:16951138}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter