Version 5.4
Homo sapiens Protein: AEBP2
Summary
InnateDB Protein IDBP-22262.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AEBP2
Protein Name AE binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266508
InnateDB Gene IDBG-22258 (AEBP2)
Protein Structure
UniProt Annotation
Function DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. {ECO:0000269PubMed:15225548}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0035098 ESC/E(Z) complex
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZN18
PhosphoSite PhosphoSite-Q6ZN18
TrEMBL G5EA50
UniProt Splice Variant
Entrez Gene 121536
UniGene Hs.595408
RefSeq NP_694939
HUGO HGNC:24051
OMIM
CCDS CCDS44842
HPRD 16477
IMGT
EMBL AB209384 AC090059 AC091805 AC137561 AK131361 AK131410 BC015624 BC022220 CH471094
GenPept AAH15624 AAH22220 BAD18513 BAD18557 BAD92621 EAW96398 EAW96400

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca