Homo sapiens Protein: SLCO1B3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-22435.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | SLCO1B3 | ||||||||||||||
Protein Name | solute carrier organic anion transporter family, member 1B3 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Protein | ENSP00000370956 | ||||||||||||||
InnateDB Gene | IDBG-22433 (SLCO1B3) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269PubMed:22232210}. | ||||||||||||||
Subcellular Localization | Basolateral cell membrane; Multi-pass membrane protein. | ||||||||||||||
Disease Associations | Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269PubMed:22232210}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||
Tissue Specificity | Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR002350
Kazal domain IPR004156 Organic anion transporter polypeptide OATP IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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PFAM |
PF00050
PF07648 PF03137 PF07690 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00280
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9NPD5 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9NPD5 | ||||||||||||||
TrEMBL | F5H8K0 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 28234 | ||||||||||||||
UniGene | Hs.504966 | ||||||||||||||
RefSeq | NP_062818 | ||||||||||||||
HUGO | HGNC:10961 | ||||||||||||||
OMIM | 605495 | ||||||||||||||
CCDS | CCDS8684 | ||||||||||||||
HPRD | 12021 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | AC011604 AC087309 AF187815 AJ251506 AJ400763 AJ400764 AJ400765 AJ400766 AJ400767 AJ400768 AJ400769 AJ400770 AJ400771 AJ400772 AJ400773 AJ400774 AJ400775 AJ400776 | ||||||||||||||
GenPept | AAG43445 CAB96997 CAB97008 | ||||||||||||||