InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSK

Summary

InnateDB Protein

IDBP-22596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSK

Protein Name

c-src tyrosine kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000220003

InnateDB Gene

IDBG-22594 (CSK)

Protein Structure

UniProt Annotation

Function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269PubMed:1639064, ECO:0000269PubMed:9281320}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lung and macrophages. {ECO:0000269PubMed:1371489}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	103 [view]
Protein-Protein	101 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030168	platelet activation
GO:0031295	T cell costimulation
GO:0032715	negative regulation of interleukin-6 production
GO:0033673	negative regulation of kinase activity
GO:0034332	adherens junction organization
GO:0042997	negative regulation of Golgi to plasma membrane protein transport
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045779	negative regulation of bone resorption
GO:0046777	protein autophosphorylation
GO:0048709	oligodendrocyte differentiation
GO:0050765	negative regulation of phagocytosis
GO:0050852	T cell receptor signaling pathway
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071375	cellular response to peptide hormone stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM